Browsing by Author "Muhammad Umer"

Now showing 1 - 3 of 3
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    A computational structural analysis of functional attributes of hypodermin a and b proteins: a way forward for vaccine development
    (Pak. J. Pharm. Sci, 2018) Irum Arif; Abdul Rauf Siddiqi; Haroon Ahmed; Inam Afzal; Muhammad Umer; Arooma Maryam; Rana Rehan Khalid; Saira Asif; Muhammad Sohail Afzal; Shabnum Shaheen; Sadaf Abdul Rauf; Ozyalin, Ozge; Simsek, Sami
    Hypodermosis is a parasitic disease of cattle. The pathogenicity of the disease is attributed to Hypodermin proteins (Hypodermin A, Hypodermin B and Hypodermin C). Studies suggest that Hypodermin proteins may be defined as Serine proteases and collagenases. The structure of both proteases Hypodermin A and Hypodermin B were modeled using the Swiss-model server followed by its validation using Procheck, Errat and Verify-3D. Afterwards, both Hypodermin A and Hypodermin B were docked against collagen in order to study its interaction with respective Hypodermin proteins. The structure of both Hypodermin A and Hypodermin B showed more bent towards hydrophobic nature as more beta sheets were present in them. Both structures were also superimposed to check out similarities and differences present between them. Serine, Aspartic acid, Histidine, Glutamic acid and Lysine are found as interacting residues that are involved in hydrogen bonding with collagen. The interactions are found in the active domain region of Hypodermin proteins. The interacting residues were present in the active region of the hypodermin proteins thus validating the docking studies. This study may help in the drug development against hypodermosis with least side effects.
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    DEVELOPMENT OF SOPS IN AK ENTERPRISES
    (umt.lahore, 2019) Hafiz Abdul Wahab; Muhammad Umer; Irfan Shahid; Hafiz Zaid Munawar; Taimoor Khan
    This study is conducted to develop standard operating procedures in supply chain department of AK Enterprises. This study provides a coordinated organizational framework to increase efficiency and interdepartmental linkages, reduction in process time, maximum resources consumption, improve credibility of process flows and increase quality and reliability of work place processes. During this research the problems that were found out through the focus group discussion are in the areas of warehouse, procurement, transport, and untrained staff showing carelessness which are causing different problems in these departments. Mismanagement arises in the loading and unloading of the goods which have dispatch issues. To overcome the hurdles affecting the company’s performance badly
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    Lawyer To Hire
    (UMT, Lahore, 2023) Jawad Ahmed Khan; Muhammad Umer; Aniza Amir; Ahmed Ali
    In our society there are women who do not have any guardian to discuss their legal matters and some women who have been opressed by their family and do not know their rights and legal proceedings to get out of it because they are not allowed to go outside of their house so what should they do in this case we have made this applicaton because they can just use their mobile phones and use this application to get advice because in this digital age everyone have phone and in every house internet connection or wireless connection exist so they can talk with lawyers and discuss their matters online about various problems like distribution of inheritance and domestion violation and there is some other group of people in which Generally people feel some kind of fear about going to court and visiting the lawyers and some people need important legal advice but they postpone just because they have no time to go to lawyer firms and discuss their matters.That is why we are making this Lawyer to hire application to solve this problem because it enables people to discuss their legal matters at their home and if they feel like they have to visit the lawyers then they book according to date and time and then have their proper meetings because through online meeting they have discuss their problems and now they have to visit they lawyers to write the document and start the execution in legal ways.