Browsing by Author "MUHAMMAD ARSLAN"

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    Formulation of haemostatic ointment based of tranexamic acid
    (UMT, Lhr, 2019) MUHAMMAD ARSLAN
    Tranexamic acid is medicine which is used for the treatment of heavy bleeding from body due to some injury or wound. It is used to stop blood loss from teeth, nose bleed. It is a type of amino acid that work to suppress the plasmin that cause inflammation. In the present work the formation of biopolymer based tranexamic acid gel formed, which will be applied on the wound to stop bleeding. Three different trials were conducted on gel. One without use of any polymer and two trials with biopolymers. Two different polymers chitosan and gelatine used in the gel formation that will enhance the stability and life of the gel. Chitosan has a property to repair wound. This gel is not for internal used, only for external use. It will be effective in the sinus surgery or nose bleeding. The test of tranexamic acid was performed on RP-HPLC-UVD for its assay calculation. In HPLC the mobile phase consists of Acetonitrile: water (65:35) used. Flow rate was 1ml/min and C18 column (4.6x250mm, 5µm) column used, column temperature set at 40oC. Tranexamic acid was derivatized using Sanger’s reagent for it detection on UV detector. It was found that gel made using chitosan polymer show better stability and compared to gelatine based gel and gel without any other polymer.