Browsing by Author "Atiqa Iftikhar"

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    Integrative network analysis to identify hub genes in metastatic prostate cancer
    (UMT Lahore, 2023-02-16) Asma Muhammad Mumtaz; Atiqa Iftikhar; Faria Faran; Rimsha Hamid Mehmood
    Metastatic prostate cancer is the leading cause of prostate cancer related deaths in men around the globe. We performed a detailed bioinformatic analysis to identify the genes involved in the metastasis of the prostate cancer. After identifying the prominent genes that may be involved in metastatic mechanism, we identified purposable drugs, targeting those genes. We identified DEGs using GEO databases. The DEGs thus obtained were validated using TCGA datasets available at GEPIA and TACCO databases. About 14 genes were found to be common in all three databases i.e., GEO, GEPIA and TACCO. Furthermore, we performed GO and KEGG enrichment analyses using DAVID database. PPI-network was constructed using STRINGS software. This network was then analyzed using Cytoscape software. Two plug-ins which were already present in CytoHubba were used for this purpose. The plug-in CytoHubba was used for identifying hub genes and the plug-in MCODE was used for the formation of clusters. Among top 10 hub genes, four genes, ADCYS, PRKG1, ESPR1 and RBFOX2, were present in 2 MCODE clusters. These 4 genes were then used as targets to identify suitable drugs from 3 databases, CMap, DrugBank and TTD. The results identified potential drugs against ADCYS and PRKG1 genes. The effectiveness of the drugs against these two genes were then analyzed by performing Molecular Docking using MOE software.
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    Stereotypes about english as second language
    (UMT Lahore, 2013) Atiqa Iftikhar
    This research work has been undertaken to assess the stereotypes about English as second language. The relation between stereotypes about English and adherence of students towards the stereotypes is explored. To take it a step further, it is examined that whether there is any relation between age, gender of students and the stereotypes about English as second language. Quantitative analysis of the topic under study involves a comprehensive questionnaire which was formulated to study the prevalence of stereotypes about English in a rational way. Given the popularity of English in the world in general and in Pakistan in particular, this research work aims at exploring that to what extent the young generation (students) is engraved with the concept of acquiring English language. The concept of English has become a metaphor for success and prosperity. This research work identifies various aspects of the stereotypes by breaking the large concept of “dominance of English” into small units so that they are identifiable and measureable as well. This research work enables to enlighten three important factors as stereotypes. These factors are English accent, code mixing, and image of target English population. The extension of scope to see how stereotypes affect age and gender of students thereby illuminates a certain pattern existent in our societal education system, along with recommendations for future research.
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    Stereotypes about English as secondary language
    (University of Management and Technology, 2013) Atiqa Iftikhar
    This research work has been undertaken to assess the stereotypes about English as second language. The relation between stereotypes about English and adherence of students towards the stereotypes is explored. To take it a step further, it is examined that whether there is any relation between age, gender of students and the stereotypes about English as second language. Quantitative analysis of the topic under study involves a comprehensive questionnaire which was formulated to study the prevalence of stereotypes about English in a rational way. Given the popularity of English in the world in general and in Pakistan in particular, this research work aims at exploring that to what extent the young generation (students) is engraved with the concept of acquiring English language. The concept of English has become a metaphor for success and prosperity. This research work identifies various aspects of the stereotypes by breaking the large concept of “dominance of English” into small units so that they are identifiable and measureable as well. This research work enables to enlighten three important factors as stereotypes. These factors are English accent, code mixing, and image of target English population. The extension of scope to see how stereotypes affect age and gender of students thereby illuminates a certain pattern existent in our societal education system, along with recommendations for future research.