Department of Physics

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Yield calculation of positron emitters for high specific activity
(University of Management and Technology Lahore, 2015) Asim Nisar Sheikh
The development of longer lived positron emitter radionuclides,(termed as non-standard positron emitters) are required to study the metabolic processes, labelling of organic compounds leading to analogue tracers (e.g. with halogens) and quantification of targeted therapy. The decay characteristics of those non-standard positron emitters (half-lives, prompt emission of associated gamma rays, positron energy and positron decay fraction) determine the qualitative and quantitative accuracy (i.e. blurring, spatial resolution, sensitivity, radiation dose, etc.) of the image, which ultimately defines their possible utilization in PET. The radioisotopes can be used in clinical trials after standard bench marking. Yield calculation is an integral part of this business. In this work, we will select some positron emitters which may be potentially important in nuclear medicine. The reaction cross section data will lead to calculate the yields. The specific activity will be estimated keeping in view the impurity level in each isotope. The recommended reaction routes will be suggested for the production of selected isotopes for medical applications.