2023

Permanent URI for this collection

https://escholar.umt.edu.pk/handle/123456789/11455

Browse

Browsing 2023 by Author "MAIRA IQBAL"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Rate and risk factor associated with poor treatment outcome of hcv
    (UMT, Lhr, 2023) MAIRA IQBAL
    Hepatitis C is a chronic viral infection infecting liver with limited therapeutic options. The available treatment options for Hepatitis C are associated with several risk factors. The recent important therapeutic options include Direct Acting Antiviral (DAA) inhibiting (Non-Structural 5-A) NS5A of “HCV”. Recently, the mixture of 2 drug DACLA plus SOFOS are most significantly prescribed for three (03) months and six (06) months; depends upon the Quantitative (RT-Pcr), Through Risk Factor for HCV also effectively of the therapeutic options in population of Lahore is yet to be explored. Henceforth, that currently studied design for the assess for this rate and risk factor associating with poor treatment outcome for HCV in Mayo Hospital Lahore. A total of 10cc of intravenous blood was collected from HCV treated patients (n=500). Risk factors was evaluated through comprehensive questionnaire. Hematological screening through complete blood counts (CBC) and serologically diagnosis of HCV through ELISA followed by molecular characterization through RT-PCR while liver examination through Ultrasound was carried out before and after treatment with DAA. A total of patients was from rural area is 93.4 % out of 500 whereas the patient from urban area is 6.4%) origin (P<0.05) where most of them was from age group (22 to 30 years). Among various risk factors major ratio is transfer to another place 17.4% patient and default ratio 15.8% was significantly associated with treatment failure Therapeutic effect of anti-HCV revealed that cured percentage is 225/500 (45%) of the patients was only cured.