Synthesis, characterization and biological studies of transition metal complexes of (e)-4-((3,5-dichlorophenyl)amino)-4-oxobut-2-enoic acid
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Date
2017
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Publisher
University of Management and Technolog
Abstract
Ligand, its sodium salt and four new metal carboxylates have been prepared and characterized by FT-IR, conductometry and UV-Visible spectroscopy. All the prepared compounds were solid and obtained in solid state. They have sharp melting points and have good yield. FTIR spectroscopy proved that there is no involvement of carbonyl group and amine group in metal-ligand coordination. Only carboxylic group was involved in complex formation. Molar conductance revealed that all the compounds are non-electrolytic in nature due to very low conductance. A broad band in copper complex (CuL2) represents the presence of water molecules. UV-Visible spectra proven that all the compounds appeared in UV region (200-400nm) have shown π-π* and n-π* which indicated that all the compounds were aromatic in nature. Different concentrations of synthesized compounds were used to for inhibition of alkaline phosphatase which proved that all the compounds possess inhibitory action against ALP.
Description
Supervised by: Dr. Khurram Shahzad Munawar
Keywords
Concentrations of synthesized, Alkaline phosphatase, MS thesis