RAHEEL RIAZ2025-12-042025-12-042019https://escholar.umt.edu.pk/handle/123456789/15051The focus of this paper is to analyze a vital molecule of the human body which is called DNA. It is not only found in human beings but also part of plants and animals. It has a lot of information about heritage and informs us that whether we are at the risk of any disease. The damage to the DNA can also change the genetic material and its structure and all the information which it contains. There is a pathway named DNA damage response to perceiving whether the DNA is harmed and also initiates the reaction to the harm. That is why it is important for DNA to develop such components which can repair the harmed DNA. Serious problems like cell passing, apoptosis or oncogenesis occurs when DNA lacks the ability within its neuron to protect itself. The lack of ability to repair DNA also causes serious infections. In this paper, we will highlight the importance of the repair proteins and discuss an efficient method to find the DNA repair proteins and get the best possible results from it. The study will use chou’s 5 step rule and some other techniques to get the best predictions by using an artificial neural network of the algorithm. The 10-fold validation method is also used to validate it on different levels and ensure overall accuracy specificity and the sensitivity. This study will play an important role and propose the fundamental part to the other studies which already exist and some predictions about the repairmen of DNA. The proposed method can offer assistance in DNA foreseeing that too in a productive and best possible way. Keywords: Proteins, DNA damage, DNA repair, DNA repair proteinsenThesis