Saima Taj2018-12-172018-12-172017https://escholar.umt.edu.pk/handle/123456789/3452Supervised by: DR. Sammia ShahidDiabetes is spreading all over the world day by day. There are many ways to treat diabetes mellitus which includes synthetic drugs, Homeopathic medicine or Unani Medicine etc. These Medicines have many side effects. Natural products include herbs, shrubs and large plants which cure diabetes mellitus and prove excellent hypoglycemic activity. These herbal medicines have no side effects. Almost all the species of family Anacardiaceae show hypoglycemic activity and used from centuries to cure diabetes. Many pistachio species show hypoglycemic activity and have a very long history of herbal remedies. The present study evaluates the hypoglycemic effect of Pistachia khinjuk. In this study, hypoglycemic effect is checked from the extract and wax of Pistachia khinjuk individually. Six groups of Swiss albino mice were made for wax and six for extract (80:20 Methanol: water) of Pistachia khinjuk separately and each group contains six albino mice. All the mice were injected alloxan monohydrate except normal group of wax and extract. Group 1 was treated as normal group and receives no treatment, group 2 receive 5mg/kg of glibenclamide after alloxan monohydrate induction, group 3 receive no treatment after alloxan monohydrate induction, group 4 and 5 receive 500 and 250mg/kg of Pistachia khinjuk extract while group 6 receives 500mg/kg Pistachia khinjuk wax after alloxan monohydrate treatment. Almost all the mice for wax (Pistachia khinjuk) of group 4, 5 and 6 show gradual increase in their diabetes while all the mice for extract (Pistachia khinjuk) of group 4, 5 and 6 show hypoglycemic activity and decreases blood glucose level. Present study indicated the hypoglycemic effect of Pistachia khinjuk for extract but indicates opposite results for wax of Pistachia khinjuk. There is a clear difference of increased blood glucose level for wax of Pistachia khinjuk. There may be many factors behind this activity which needs more research on it by detecting and analyzing specific compound which cause this effect. The methanolic extract due to phenolic constituents proves to be excellent antidiabetic medicine.enHomeopathic medicine, Diabetes, Pistachia khinjuk,MphilThesis