Hifza Sibtain2018-07-312018-07-312017https://escholar.umt.edu.pk/handle/123456789/3049Supervised by: Dr. Sohail NadeemAlkaloids exist in monochrome crystalline form and heterogeneous solid powders that are more soluble in ethanol, ether, and chloroform but less or insoluble in H2O. Alkaloid benzophenanthridine also known as isobenzylacinone derived from the roots of Bloodroot. Sanguinarin has been initiate to give more than 50% of the S. canadensis part rhizome in dry condition. Sanguinarine nitrate commonly known as salt of sanguinarne. Antibacterial study was conduct on it by agar diffusion well-variant method and medicated fabric was formed by sol gel method and antibacterial study was conduct by agar diffusion disc variant method. The study was conducted on three bacteria's E. coli, S. aureus and B. spezzani species. Results that was obtain showed that sanguinarine as a quaternary ammonium salt have high efficiency of 43 % in agar diffusion well-variant method and 42% in agar diffusion disc variant method on medicated fabric toward Staphylococcus aureus. Dilution 10μg/L show high efficiency that is also a save dose range while dilution 8μg/L and 6μg/L show results comparatively low and respectively degrade.enSanguinarin has been initiateStaphylococcus aureusMSThesis