Khurram Shahzad Munawar2018-11-242018-11-242016Munawar, K. S., Ali, S., Khalid, N., Tahir M. N., & Abbas, S. M. (2016). Vanadium-Catalyzed Esterification of Carboxylates: Synthesis, X-Ray Crystal Structure and Biological Studies. Chemistry Journal, 6(1), 1-9. (Khurram Shahzad Munawar (Chemistry/SSC), (NOT RECOGNIZED BY HEC))2049-954Xhttps://escholar.umt.edu.pk/handle/123456789/3446The potentials of vanadium (III) chloride as catalyst were checked for the esterification of substituted carboxylic acids with methanol. The synthesised precursors and methyl esters formed were characterised by various analytical techniques such as FT-IR, 1H-NMR, 13C-NMR and single crystal analysis. The antimicrobial activities of the carboxylates and their methyl esters were found good against various strains of bacteria (Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Pasteurella multocida) and fungi (Alternaria alternata, Ganoderma lucidum and Penicillium notatum). All these esters were tested for their activity against the alkaline phosphatase (ALP) and Methyl 4-oxo-4-(2,4,6-trichlorophenylamino)but- 2-enoate (compound 1) was found to be potent inhibitor while Methyl 4-(3,4-dichlorophenylamino)-4-oxobut-2-enoate (compound 2) showed intercalative mode of binding with DNA.ChemistryVanadium, Coordination Modes, Vibrational Spectroscopy, Antimicrobial Activities, Bacteria, Fungi