Muhammad Ishafq Ahmad2018-04-132018-04-132017https://escholar.umt.edu.pk/handle/123456789/2999Supervised by:Dr. Sammia ShahidLow solubility and bioavailability was the major concern in the past for macrolide antibiotic drugs. The solubility and dissolution rate could be enhanced by preparing nanodrugs as their surface area increases. In this research clarithromycin drug nanoparticles were prepared by using solvent-antisolvent precipitation method. The prepared drug nanoparticles were characterized by FTIR, SEM, EDX and XRD. Dissolution rate was studied by using Dissolution apparatus and High Performance Liquid Chromatography (HPLC) at different time intervals was used. The dissolution rate of nano drug showed a major enhancement as compared with the parental drug. No difference was observed in IR spectra of both parental drugs and nano drug of clarithromycin. X-Ray diffraction (XRD) showed the amorphous form of clarithromycin. The SEM images showed the nanosized particles of nanodrug. The antibacterial activities of both parental drug and nanoparticles were determined against Staphylococcus aureus, E. coli, and Salmonella typhi by agar well diffusion method. The nano drug showed better results as compared to the parental drug.enClarithromycin; High Performance Liquid ChromatographyNanodrugs; Macrolide AntibioticsMS thesisThesis