Mahnoor waheed2025-08-222025-08-222022https://escholar.umt.edu.pk/handle/123456789/5118There has been a change in etiological reasons for depression and the accepted understanding of how the brain and body operate, with the former being blamed on an excess of black bile and the latter on poor neuroplasticity and neuroimmune functioning. The chemical imbalance theory proposes that the depressed person's brain has an insufficient amount of monoamines, specifically serotonin, and that this is the biochemical cause of depression. There are several academic arguments against the chemical imbalance theory being able to provide a satisfactory explanation for depression and its therapy.en-USThesis