ATTIQA SHEHZADI2025-12-032025-12-032022https://escholar.umt.edu.pk/handle/123456789/15001Nanoparticles are a wide range of small particles having the size of between 1 100 nanometers. Similarly, silver nanoparticles are nanoparticles made of silver having the same size as nanoparticles. They have been widely used in different branches as well as medicine, health maintenance, food, and commercial use, etc. Silver nanoparticles could be harmful to normal cells in the body regulated by different concentrations and the time-spam of exposure. Besides its harmful effects, it is best for wound healing and killing the bacteria that cause infection. In the past, silver was used as a natural antibiotic. In this study, Silver nanoparticles are conjugated with curcumin and folic acid by the glutaraldehyde method having anti cancer properties. Curcumin is an active compound to kill cancer cells and folic acid is an organic form of vitamin-B9 that will create and preserve the new cells from cancer. Silver nanoparticles are interacted by PEG (Polyethylene Glycol) and further conjugated by Folic acid (C19H19N7O6) and Curcumin. Curcumin is attached to the NH2 – ion connecting with PEG and folic acid is attached to the carbonyl group connecting with PEG. Average crystalline sized Silver Nanoparticles are much more beneficial as compared to chemotherapy and many other radio-therapy cells to kill tumor cells.enThesis