Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2802
Title: Analysis of lemon grass for its antifungal value
Authors: Azeem, Sidra
Keywords: C. citratus components for fungal inhibition. Phytochemical
Antifungal activity of C. citratus extracts
MS thesis
Issue Date: 2017
Publisher: University of Management and Technolog
Abstract: Medicinal plants are still a major part of traditional and herbal medicine in the developing countries. The use of medicinal plants is common among those people who have less or no access to prescribe medicine. Cymbopogon citratus (C. citratus) is commonly known as "citronella grass" or "lemongrass" that belongs to family Gramineae (Poaceae). It is a perennial tropical grass with long, thin leaves. Lemon grass is found as a folk remedy for fever, pneumonia, antispasmodic, antipyretic, bactericidal, fungicidal, antioxidant, analgesic, anti inflammatory actions and astringent properties. Antioxidants isolated from C. citratus are responsible for reducing LDL (low-density lipoprotein) oxidation, scavenging activity of free radicals and high potential on human skin. The fundamental aim of this study was to extricate different C. citratus components for fungal inhibition. Phytochemical tests were performed to confirm the presence of alkaloids, flavonoids, tannins, coumarine and saponins. The extracts showed significant antifungal and antioxidant activities. The antifungal activity of C. citratus extract against Candida albicans and Sacchromysis cerevisiae was explicated by using the agar diffusion method. Nystatin was used as standard to measure the antifungal activity of C. citratus extracts. In this study, the results clarify that all C. citratus extracts exhibited clear zone of inhibition against tested fungus but methanol extract of C. citratus was superficially effective against Sacchromysis cerevisiae and showed 24mm zone of inhibition after 72h.Wherase, methanol extract of lemon grass against C. albicans showed 19mm zone of inhibition after 72h. Antioxidant activity of C. citratus samples were also reported by TPC method. Methanol extract of C. citratus corroborated highest antioxidant activity followed by hexane and water extracts. Maximum absorption for methanol was GAE 1190.6 mg/L and water was GAE 530.9 mg/L whereas n-hexane showed less absorption. Results declare that leaves of C. citratus can be a part of herbal medicines that can be used against fungal diseases.
Description: Supervised by: Dr. Ayesha Mohyuddin
URI: http://hdl.handle.net/123456789/2802
Appears in Collections:Department of Chemistry

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